Mouse study finds molecule repairs heart tissue to avoid damage
A study in mice finds treatment with a molecule called MCB-613 repairs heart tissue after a severe heart attack, preventing damage that can lead to heart failure. The findings are being presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.
“This is a remarkable discovery that may lead to effective and safe treatments to prevent the progression to heart failure after a heart attack,” said lead researcher Lisa K. Mullany, Ph.D., of Baylor College of Medicine in Houston.
Heart failure after a heart attack is the leading cause of death in humans, and currently there are no definitive therapies other than heart transplantation.
Researchers had previously found that MCB-613 stimulates proteins called steroid receptor coactivators (SRCs). These proteins are responsible for cellular changes and growth during both normal and abnormal tissue growth. After a heart attack, the damaged tissue…
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